The HR for suicide in active smokers in 1975 and 1981 was reduced from 3.27 to 2.90 and 2.85, respectively, in models containing problem alcohol use variables but remained highly significant. In the multivariable analysis of smoking and these potential confounders, the HR for suicide in active smokers relative to never smokers dropped to 2.14 (95% CI 1.33–3.45) in the model with all cohort members (n = 138 cases from 1981 onwards in 1810 persons). In this model, LSS in 1975 and 1981 and binge drinking were also independently associated with suicide. In a model with the same covariates that excluded persons with active or future use of antipsychotic medications or disability pension due to psychiatric illness, the HR for active smokers was 2.56 (95% CI 1.43–4.59) (Table 4).
