enhanced mPFC Granger lead strength towards the periphery for anxious mice (Figure 8F; p=.026, MLR) but not non-anxious mice (p=.565). It is notable that anxious and non-anxious animals were equally likely to go on to be discriminators (56% and 66%, respectively), suggesting that these results reflect a continuously evaluated representation of safety, rather than persistent animal-to-animal circuit differences. Taken together, these data support BLA fast gamma coupling to mPFC input as a safety signal in both learned and innate fear paradigms.
