of the OPC rather than developmentally independent subclasses of OPC 26, 27, 28, 53. Since OPCs in this study are examined after a period of 1 week in oligodendrocyte differentiation medium, it may be argued that the early processes of oligodendrocyte differentiation may have already been initiated in OPCs leading to a reduced expression of Na V‐channels. Nonetheless the spiking activity and Na V‐channel current density data obtained from hPSC‐derived PDGFRα+‐OPCs are directly comparable with populations of NG2+‐cells in postnatal murine gray and white matter 26.