100% (8/8) variants with PP equal to 1 and 92% (69/75) variants with PP >0.5. These variants with high PP were very easy to distinguish from others and were more likely to be causal. One of the eight variants with the highest PP, rs11556924, was also supported by four additional CAD GWASs in CAUSALdb, with average PP of 0.955 (Supplementary Figure S9B and Table S6). This missense variant has been reported to disrupt NIPA function and plays a critical role in cell cycle regulation (50).
