Neurons might share other transcriptional dynamics in common. To identify such signatures, we looked for transcriptional patterns that, despite being ascertained in different regions or neuronal classes, involved similar gene combinations. Analysis of pairwise correlations across neuronal IC gene loadings revealed three prominent correlation blocks (Figure 3A). One such block included 15 inter-correlated ICs representing IEG-expression signatures from different regions and neuronal types. A second block arose from diverse thalamic neurons, suggesting a tissue-specific transcriptional program. We focused on the third correlation block, which consisted of ICs from many brain regions and neuronal types.
