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Chunk #6 — Background

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A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls - a large case control study.
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Given that altered brain connectivity is considered a typical characteristic of ASD, a number of studies have compared EEG coherence findings between ASD and neuro-typical control populations [21-28]. On a frequency by frequency basis, EEG spectral coherence represents the consistency of the phase difference between two EEG signals when compared over time. According to Srinvasan et al. "...coherence is a measure of synchronization between two... (EEG)...signals based mainly on phase consistency; that is, two signals may have different phases... but high coherence occurs when this phase difference tends to remain constant. In each frequency band, coherence measures whether two signals can be related by a linear time invariant transformation, in other words a constant amplitude ratio and phase shift (delay). In practice, EEG coherence depends mostly on the consistency of phase differences between channels" [29]. High coherence values are taken as a measure of strong connectivity between the brain regions that produce the compared EEG signals [30].