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Chunk #9 — Results — Comparison of small-world metrics in the AD and control groups

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Network analysis of intrinsic functional brain connectivity in Alzheimer's disease.
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In the frequency interval between 0.01 to 0.05 Hz, we examined λ and γ values in the two groups. For group comparison, we controlled for the average correlation value (r). r is different across groups. Thus, for a given correlation threshold, the number of edges in the graph are likely to be less in AD, resulting in high λ and low γ values. To ensure that graphs in both groups had the same number of edges, individual correlation matrices were thresholded such that the resultant graph had exactly K′ edges. K′ is the average number of edges in the graph obtained by thresholding individual correlation matrices with R = ri (ri is the average correlation value for subject i, i = 1 to 39). The value of K′ selected according to this procedure was 40 for both the groups. Mean λ, mean γ, and mean σ values for the networks of the AD group and control group were derived by thresholding the correlation matrices such that the network has K′ ( = 40) edges (shown in Figure 2). Results were: