no association was found between tuberculosis and ADH1B and there is no genome-wide evidence for natural selection at the ALDH2 locus, this finding may suggest a role of alcohol-metabolism genes in the predisposition to infectious diseases, which are the most-recognized environmental factors that have shaped the human genome during its evolutionary history [Daub and others 2013]. A phenome-wide association study (PheWAS) in a large Asian cohort could help to direct future evolutionary investigations of ADH1B locus.
