any drug with an attribute of ‘immunosuppressive agent’, ‘immunomodulatory agent’ or ‘immunostimulant’. Clinically actionable genes are genes that constitute the DGIdb ‘clinically actionable’ gene category, and by definition is used to inform clinical action (e.g. the Foundation One diagnostic gene panels). Similarly, druggable genome genes are genes listed in the DGIdb ‘druggable genome’ gene category (8,11,13,15–19). Drug resistance genes are defined by the Gene Ontology as genes that confer drug resistance or susceptibility (GO identifier 0042493), and are maintained in the DGIdb through the ‘drug resistance’ gene category (13). To incorporate these new filters, we have redesigned the data model, expanded the definition of the druggable genome and restructured the user interface (UI) to include a redesigned search form and results interface. The UI also now features drug, gene and interaction views to leverage the new grouping strategies and preset filters.
