intercellular channels to allow transport between cells, and at PRAG1, a pseudokinase that interacts with cytoplasmic tyrosine kinase (CSK), which ultimately affects antibacterial immune response67. Combined with a strong signal at the MHC locus, this once again suggests adaptation in immune system function. We also find evidence of positive selection at two alcohol metabolism genes at mutations known to confer protection against alcoholism: the R48H polymorphism (rs1229984) in ADH1B68,69 and the E504K polymorphism (rs671) in ALDH270,71.
