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Chunk #0 — INTRODUCTION

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Genome-wide association study of Tourette's syndrome.
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Tourette Syndrome (TS) is a chronic, childhood-onset neuropsychiatric disorder characterized by multiple motor tics and at least one phonic tic that persist for greater than one year.1-2 TS has a population prevalence of ~0.3-0.8%, and, like many neurodevelopmental disorders, occurs more frequently in boys, with male:female ratios ranging between 3:1-4:1.3-4 It is frequently accompanied by a wide range of additional psychiatric co-morbidities, in particular obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD).5 TS causes substantial physical and psychosocial morbidity in children and adolescents, and can produce lifelong disability in severe cases.6-7