Whilst the location of activation in these three studies (Diaconescu et al., 2017; Lockwood et al., 2016; Will et al., 2017) appears to be predominantly in the subgenual anterior cingulate cortex, particularly in areas 25 and 24s (as characterised by Palomero-Gallagher et al., (2015) and see Figure 1 for overlap) it is also important to consider adjacent regions to sgACC and the labels used to define this particular area. Posterior portions of the sgACC with the septal-anterior hypothalamic area that is part of the basal forebrain (Zaborszky et al., 2008) and can also extend into the ventral striatum (as in Will et al., 2017) and orbitofrontal cortex (OFC). However, the extent to which these areas play a domain-general or domain-specific role in social decision-making appears to differ (see Wittmann et al., (2018) for a review of ventral striatum and OFC in social behaviour). The ventral striatum tracked prediction errors in both the Diaconescu et al., (2017) and the Lockwood et al., (2016), but in a way that is suggestive of a domain-general response to learning about the unexpectedness of outcomes.
