There were two subclusters of both D1- and D2-type neurons, representing matrix and striosome compartments37, based on expression of genes specific to either the matrix or striosome regions of the striatum33 (Supplementary Fig. 4). 80% of D1 neurons and 83% of D2 neurons were within the matrix compartment, which makes up approximately 85% of the striatum37. There was no significant difference in subcluster proportion by AUD status in either astrocytes or D1- and D2-type neurons.
