All probands were recruited from alcohol or other substance dependence treatment facilities, and met DSM-IIIR criteria for alcohol dependence and Feighner definite criteria (COGA criteria). In addition to the probands, the study required two additional first-degree relatives who were alcohol dependent by the same COGA criteria on direct interview. Semi-Structured Assessment for the Genetics of Alcoholism, SSAGA, a polydiagnostic instrument designed by COGA with well-established reliability (Bucholz et al., 1994) and validity (Hesselbrock et al., 1999), was administered in person to determine psychiatric diagnoses in all family members. Subjects completed a neuropsychological battery and family history questionnaire and EEGs/ERPs were recorded.
