Statistical differences of neuronal densities between different striatal and Acb regions were assessed using Kruskal-Wallis non-parametric statistical test. Differences between sham and 6-OHDA-lesioned mice regarding neuronal densities and spontaneous rotations were assessed with Mann-Whitney non-parametric test. Variations in immunoreactivity for TH and DAT between sham and 6-OHDA-lesioned mice were detected using the Mann-Whitney statistical test. A Sholl analysis with 15 μm increments was used to determine the spine density and statistical differences for dendritic morphology (number of branching points, spine density and dendritic length) and for cell body diameters between the two experimental groups and the three types of MSNs were assessed with the two-way analysis of variance (ANOVA) followed by a Bonferroni multiple comparison test. All statistical tests were performed using GraphPad Prism software (v. 6.01; GraphPad Software, San Diego, CA, USA). Mean and standard error of the mean are used throughout the text as central tendency and dispersion measure, respectively.