dysfunction is linked to lysosomal storage disorders such as Krabbe disease, are consistent with the findings on the role of lysosomal pathways in PD.36,37,38 In the GPNMB/NUPL2 locus, the PD GWAS results suggest only 1 independent signal, while the results presented in this article nominate both GPNMB (gene level) and NUPL2 (splicing) with strong PPI evidence connecting both to mendelian or sporadic risk genes. This could be explained by the true causal gene being 1 of the 2, a single mechanism mediated through the associations with both genes, or potentially yet undetected independent PD GWAS signals at the locus associated with independent risk genes.
