an interaction between cannabinoids and stress in the activation of the amygdala, which may provide a context for understanding the affective changes observed following marijuana use (Patel et al., 2005). Specifically, increased c-Fos expression has been shown within the central amygdala (CeA) in mice following a combination of restraint (stress) and CB-1 agonist administration. This finding underscores the importance of considering this region when attempting to understand the relationship between the emotional and affective changes related to marijuana use and the potential interactive role of the endocannabinoid system.
