Analyses were conducted on a day-level dataset in which each medication coverage date was identified. All analyses were conducted via SAS® 9.4. Prior to evaluating variation in medication exposure between case and control days, we calculated descriptive statistics for the primary analytical sample (i.e., participants who had non-fatal drug-related poisonings). To compare OUD treatment characteristics between those with and without poisoning events, we obtained a random sample of persons who never experienced poisonings, for which we compared descriptive statistics of those who had poisoning events (eMethods 2, eTables 3–4).
