We identified 120 GWS (p<5.00E-08) lead SNPs (r2<0.1) located in 88 independent loci (Supplementary Table 7). All genome-wide significant loci had been reported by prior smoking GWAS (Supplementary Table 7), including aspects of smoking initiation (88/88), age of initiation (14/88), consumption (38/88), cessation (48/88) and nicotine dependence (1/88; Supplementary Figure 2, Supplementary Figure 3). While all these loci were recently discovered in a GWAS of 3.4 million individuals in the GSCAN study,13 here we reproduce some of the GSCAN findings with a considerably smaller sample size (Supplementary Figure 3).
