Replication of the association between the SNP (rs472402) in SRD5A1 and baseline positive affect appeared to be a more tractable problem because multiple GWAS datasets that include measurements of personality traits are available. Although our questionnaires were designed to detect differences in mood state, the effect persisted regardless of session or time point, which is consistent with a difference in trait independent of drug or session effects. We examined SNPs in strong LD with rs472402 in subjects from the National Institutes of Health/National Institute of Mental Health (NIH/NIMH) bipolar genetics studies with personality trait data consisting of the ZKPQ (n = 1007) and TCI (n = 944) subscales [87]; none of our analyses provided evidence of replication. However, the differences in the phenotypes and the study design were substantial between these studies and our own; this may indicate a poor fit for replication. We also considered the baseline sessions from smaller datasets collected in our lab using similar methodology but testing different drugs, however none of these datasets showed convincing evidence for replication. Taken together these results do not support the association between rs472402 and baseline positive affect.
