One of our primary considerations in RAREMETAL was support for standard, easy-to-implement input formats. RMW uses Merlin format input files (Abecasis et al., 2002) to retrieve phenotypes, covariates and family structure and VCF files to retrieve genotypes (Danecek et al., 2011). Checks are implemented for a variety of problems in input files, including formatting errors, X-linked genotypes that are inconsistent with reported sex and matching of identifiers across files.
