Using RMW, generating per study statistics in a recent analysis of exome array genotypes at 238 000 markers in 2000 individuals required between ∼9.1 min (unrelated samples) and ∼26.8 min (using genomic relationship). Using RAREMETAL, meta-analysis of 23 studies (sample size of ∼51 000) required ∼40 min to produce single variant and all available gene-level association test results across ∼18 000 genes.
