For estimating changes in the indicators at the European level, the oldest and most recent data points were selected and reported. For prevalence of use, at least one of these two points was not available in four countries (Austria, Estonia, Greece, Malta), which were excluded from estimating changes. The difference in adult and age-specific prevalence of use as well as for THC levels did not account for the degree of uncertainty associated with each point estimate, as these data were not available from the EMCDDA data repository. Respective confidence intervals thus only consider between-country variation of point estimates and should thus be interpreted cautiously.