PS1 FAD mutant line,44 and age-related NFT-like inclusions have been described in a PS1 knock-in line.45 Recently, a microvascular pathology that is highly reminiscent of the microvascular pathology found in AD has also been described.46 Thus, presenilin FAD mutant mice exhibit a phenotype. What is less clear is why they fail to exhibit the full range of AD-related pathologies, given the potency of the mutations in humans.
