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Chunk #21 — Results — Bioinformatics and Expression Analyses of FRMPD1 and HIV-1

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Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.
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located farther away in exons 4/5, in two independent datasets (the MuTHER resource P = 0.962; Stranger et al. 2012[37]; P = 0.567). The ILM_2089616 probe with suggestive corroborating evidence was not available in the Stranger et al. 2012 data. Finding evidence of reduced expression of FBXO10 associated with the rs4878712-G allele from two datasets with probes near the 3’ end of the gene but not for a probe toward the 5’ end of the gene may reflect differences in quality of the expression signal from the different probes or the probes tagging different gene transcripts (S10 Fig.).