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Chunk #5 — 2. Methods — 2.2 Assessments

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Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
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CD was assessed among adolescents utilizing the Diagnostic Interview Schedule for Children (DISC), which has shown discriminative validity in the study population (Crowley et al., 2001). Early study participants were evaluated with DISC2.3, which assesses DSM-III-R diagnoses. Once available, DISC-IV was utilized; DISC-IV was locally modified to allow assessment of DSM-III-R criteria, allowing combined analyses of III-R diagnoses across study years (Schulz-Heik et al., 2008).