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Chunk #19 — RESULTS — Behavioral effects of social isolation

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Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats.
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elevated plus maze, isolates also engaged in fewer stretch-attend postures (Rearing main effect: F1,28 = 105.33, P = 0.000; η2 = 0.769; Data not shown) and head dips (Rearing main effect: F1,28 = 18.40, P = 0.000; η2 = 0.412; Data not shown). In the prepulse inhibition test, isolates exhibited a lower % PPI relative to group-reared rats (Rearing main effect: F1,28 = 42.53, P = 0.000; η2 = 0.451; Fig. 1e). The deficit in % PPI observed in isolates was not global, as there was no difference in acoustic startle amplitude between groups (P > 0.05; Fig. 1f).