by which GABRA2 conveys risk (and conversely, does not convey risk) to externalizing behavior. This information will be critical to identifying those individuals most at risk for the eventual development of problems and to intervene and disrupt gene-disorder relationships. Additionally, the findings caution against applying a ‘one-size-fits-all’ approach to replication of genetic association results; rather, careful attention needs to be paid to the theory surrounding how a particular gene is likely to be involved in clinical outcome, what is known about the developmental progression associated with the clinical disorder under investigation, and how the characteristics of the sample under study fit into that broader picture.
