statistics produced using Genomic SEM. We ran PGS analyses using a p-value threshold of 1.0 (i.e., we used all available SNPs apart from those removed due to QSNP analyses). In order to maintain comparability, PGSs for the univariate summary statistics were constructed based on the same SNPs with which the PGSs for the p-factor were constructed. In the confirmatory factor models, we included controls for age, sex, genotyping array, and 40 principal components of ancestry in conjunction with the PGS predictor.
