induced by direct current injection but reduced the duration, amplitude, and spike activity of spontaneous up-states. These effects occurred at the beginning at 17mM (~0.08% blood ethanol concentration) and persistent activity of PFC neurons was almost totally suppressed at 50mM ethanol. Up-state duration was affected at lower concentrations of ethanol (25 mM) than was up-state amplitude, although both measures were reduced as ethanol concentrations were increased. Following washout of the ethanol solution, up-state duration and spiking were often enhanced as compared to pre-ethanol control values and this rebound in activity persisted for 10–15min post washout.
