transcripts (Figure 1). A small subset of transcripts did, however, share a significant and similar regulation for cocaine, cannabis and phencyclidine use cases. Functional annotation of the shared transcripts demonstrated a consistent regulation for three functional groups, including a decrease in calcium/calmodulin-related transcripts, and increased expression of Golgi/ER-related transcripts and cholesterol/lipid-related functions, suggesting that altered intracellular trafficking and neuroplasticity may be common functional consequences of cocaine, cannabis and phencyclidine use.
