Our study also allows us to look for loci which may have an effect in more than one disease. To assess this, we compared our common controls with all cases in each of three natural groupings of diseases: CAD+HT+T2D (metabolic and cardiovascular phenotypes with potential aetiological overlap, for example, involving defects in insulin action); RA+T1D (already known to share common loci); and CD+RA+T1D (all autoimmune diseases).
