To our understanding, RICOPILI is the only open-sourced GWAS pipeline allowing secure data management, efficient data processing and downstream analysis scalable on both desktop and cluster environment. First, RICOPILI features an integrated quality control (QC), imputation and association analysis within its framework. Second, RICOPILI allows more than one imputation approach and reference panel to be utilized within its framework. Furthermore, computer intensive imputation can be processed locally within a closed cluster system. Third, the RICOPILI framework allows scalable processing of GWAS data, from a single CPU, to a cluster set up, or even within the cloud-based systems.
