To test for convergence of risk conferred by common variants and rare protein-truncating variants (rPTVs), we analyzed whole-exome sequencing data from a subset of the iPSYCH cohort consisting of 8,895 ADHD cases and 9,001 controls. We tested three gene sets: (1) the 76 prioritized risk genes identified by positional and functional annotation, (2) the 45 significant genes in the MAGMA analysis, and (3) 18 genes with at least five credible variants located in the coding region (Supplementary Table 16). While there was no indication of increased burden of rPTVs in the first gene set (P = 0.39, OR = 1,30, s.e. = 0.16), the second gene set showed borderline nominal significant enrichment (P = 0.05, OR = 1.43, s.e. = 0.18), and the set of genes identified based on credible variants had a significantly increased burden of rPTVs in individuals with ADHD compared to controls (P = 0.015, OR = 2.19, s.e. = 0.32). For comparison, there was no enrichment in rare synonymous variants in the third gene set (P = 0.59). When evaluating the 18 genes from the “credible
