and CTCF-binding sites using a Weibull distribution (r2 > 0.999) and predict saturation at approximately 4.1 million (S.E. = 108,000) and 185,100 (S.E. = 18,020) sites, respectively, suggesting that we have discovered around half of the estimated total DHSs. These estimates represent a lower bound, but reinforce the observation that there is more non-coding functional DNA than either coding sequence or pan-mammalian constraint.
