Chunk #47 — DISCUSSION — Cellular mechanisms associated with trafficking of GluR1-containing AMPARs toward synaptic junctions

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Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study.

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Besides the GluR1-containing AMPARs, previous studies have revealed changes within intact LA of at least five other synaptic proteins following fear conditioning: Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) (Rodrigues et al., 2004a); myosin light chain kinase (Lamprecht et al., 2006b); the activity-regulated cytoskeletal-associated protein Arc/Arg3.1 (Ploski et al., 2008); profilin (Lamprecht et al., 2006a); and spinofilin (Radley et al., 2006).