In secondary analyses, we compared PolyLoc to an alternative method that performs polygenic localization based on prior estimates of per-SNP heritability from functional annotations, rather than posterior estimates. This alternative method uses per-SNP heritability estimates and SNP bins from step 4 of PolyFun, based only on the N=337K dataset (noting that it does not suffer from winner’s curse because PolyFun applies a partitioning into odd and even chromosomes).
