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Chunk #34 — 5.0 Lessons Learned from the Minnesota Twin Family Study Investigation of 17 Candidate Endophenotypes — 5.1 Project overview

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Endophenotype best practices.
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constituting the largest sample ever used for this purpose, we carried out in parallel a series of seven investigations designed to identify molecular genetic variants associated with 17 psychophysiological variables involving EEG frequency-based measures, P300 oddball visual event-related potential, antisaccade eye tracking, startle eye blink, and electrodermal activity (W. G. Iacono et al., 2014b; Malone et al., 2014; Vaidyanathan, Isen, et al., 2014; Vaidyanathan, Malone, Donnelly, et al., 2014b; Vaidyanathan, Malone, Miller, et al., 2014; Vrieze et al., 2014a, 2014b). The measures chosen represent a broad range of basic and complex psychological processes that tap into central and autonomic nervous system arousal, startle, orienting, habituation, emotion, cognition, and prepotent response inhibition.