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Chunk #19 — 1.2 ANATOMY OF eCB SIGNALING IN THE AMYGDALA — 1.2.2 FAAH

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Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.
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Similarly, Elphick and co-workers described FAAH immunoreactivity within the somata of neurons throughout the BLA (Egertova et al., 2003). Furthermore, Freund and co-workers, using an antibody generated against a native 6X-His tagged truncation of FAAH (Bracey et al., 2002), also published detailed light and EM descriptions of FAAH within the rat and mouse amygdala (Gulyas et al., 2004). At the light microscopy level, a strong cellular (cytoplasmic and proximal dendritic) and granular/reticular neuropil staining was observed within the BLA. In the CeA, only occasional neurons were FAAH immunoreactive (Gulyas et al., 2004). At the EM level, FAAH was present postsynaptically within dendrites and somata of BLA neurons. FAAH was localized to dendritic shafts and spine heads, but not axon terminals (Gulyas et al., 2004).