paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #5 — ONLINE METHODS — Meta-analysis of discovery studies

Source
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Embedded
yes

Text

after only the first GC correction (see Supplementary Table 2) because a second GC correction is generally considered to be over-conservative32. We additionally selected SNP rs6537307 (P=4.3×10−5), which is in linkage disequilibrium with a known HHIP height-associated variant (HapMap r2 = 0.58 with rs685478333). Of the 22 selected SNPs, rs1004059 at SYNP02L (P = 2.3×10−6) was available in only 8 studies since its MAF was close to 0.01. After obtaining data from this SNP from all available Stage 1 studies, we observed a meta-analysis P-value of P = 6×10−5, and so did not consider it further.