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Chunk #14 — Methods and Materials — Statistical Analysis

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Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
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of POMC variants on the three disease traits (AD, CD, or OD) was investigated under three models (additive, dominant, and recessive). The disease trait was the dependent variable, and sex, age, and the probabilities of alleles, genotypes, or haplotypes were served as covariates. The probability of each haplotype for each subject was approximated using the logistic regression analysis incorporated in the HelixTree software.