Analysis of the imputed genetically regulated gene expression suggested CHRNA2 underexpression in cerebellum (and probably other brain regions), to be involved in CUD. Cerebellum may play a role in addiction with respect to reward and inhibitory control34, and reward-anticipating responses35. Cerebellum has high density of cannabinoid receptor 1 (CB1), which mediates the effect of delta9-tetrahydrohydrocannabinol (THC), the psychoactive compound in cannabis and has also been found to be affected by cannabis use in neuroanatomic studiese.g.36.
