2016]) are very likely not related to alcohol consumption, mainly because ALDH2, the other locus affecting alcohol drinking behaviors in Asians (and with an even stronger effect), does not show any genomic selection signature. Both our PheWAS and the evolutionary evidence strongly suggest that ADH1B should present other functions with relevant effects on the human phenome and further studies based on phenome-scan and polygenic adaptation [Polimanti and others 2016c] are needed to clarify the role of ADH1B in human evolution. Our recent genome-wide gene-by alcohol dependence analysis of risky sexual behaviors also indicated that alcohol dependence and its risk alleles may moderate the predisposition to risky behaviors [Polimanti and others 2016b]. Due to its large effects on alcohol dependence, ADH1B is a strong candidate to be investigated in relation to risky behaviors.
