There is not one set description or classification of M2 cells. In fact, there are many efforts to identify unique sub-groups with different functions. Division of M2 cells is based on observations that stimulation with various cytokines yields different sets of receptor profiles, cytokine production, chemokine secretion, and function [21]. Even though the profiles of these cells are diverse, the one feature that places them all in the M2 classification is that they express mediators or receptors with the capacity to downregulate, repair, or protect the body from inflammation [24].
