Chunk #8 — Results — Electrophysiological profiles of differentiated neurons

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Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern.

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potential (RMP, Fig. 5E, D4 -30 ± 2.3 mV, n = 25; D7 -31.8 ± 2 mV, n = 29; D24 -34.7 ± 2.5 mV, n = 21; D38 -36.8 ± 1.6 mV, n = 26) and membrane resistances showed a decreasing trend (Rm, Fig. 5G, D4 3.05 ± 0.4 GΩ, n = 31; D72.59 ± 0.3 GΩ, n = 32; D24 2.2 ± 0.24 GΩ, n = 25; D38 2.15 ± 0.19 GΩ, n = 26). The membrane capacitance increased after differentiation was induced (Fig. 5F, D410.6 ± 1.7 pF, n = 31; D7 17.2 ± 1.5 pF, n = 32; D24 27.6 ± 1.9 pF, n = 25; D38 32 ± 2.7 pF, n = 26).