NAP [Bassan et al., 1999; Magen and Gozes, 2014]. The mechanism of action is believed to involve P53, a key regulator of cellular apoptosis, as silencing of ADNP results in an increase of p53 [Zamostiano et al., 2001]. Subsequently, it was shown that addition of NAP to PC12 cells subjected to oxidative stress protected the cells against elevated p53 levels, normally caused by this treatment [Gozes et al., 2004]. ADNP2 is a sister protein to ADNP which is 33% identical at the protein level, shares the zinc finger and homeobox domains, but lacks the NAP motif [Zamostiano et al., 2001]. Expression levels of ADNP and ADNP2 appear to be correlated [Dresner et al., 2011; Helsmoortel et al., 2014b].
