Chunk #17 — Results — Integrating Genetic and Network Data across Species to Inform GWA Discoveries — Identifying candidate susceptibility genes for T1D.
In one of the largest GWASs carried out to date, the Wellcome Trust Case Control Consortium (WTCCC) studied 14,000 cases and 3,000 shared controls with respect to seven common diseases [14]. T1D was one of the key disease focuses of this study, with a number of replications reported simultaneously in a separate follow-up study [15]. In addition, a number of T1D susceptibility genes identified prior to the WTCCC study have been identified and more thoroughly replicated, including the HLA class II genes INS, CD25, CTLA4, PTPN22, and IFIH1. Given that the SNPs genotyped in the WTCCC study were also genotyped in the HLC, we examined the extent to which the T1D SNPs identified in the WTCCC study were associated with the expression traits corresponding to the genes implicated in the study.
