Chunk #18 — RESULTS — Individual low frequency CHRNA5 variants

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Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.

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In secondary analyses using Multivariate Model Set 2, we examined the independent contributions of the three low frequency variants to nicotine dependence risk controlling for the effect of other CHRNA5 coding variants. One of these low frequency variants was found primarily in European Americans, and the other two were almost exclusively in African Americans (Table 2).