Here we investigated consequences of hepatocyte-specific Pparα deletion, focusing on effects on fatty acid metabolism in NAFLD, ranging from steatosis to steatohepatitis. We report the first evidence that adipocyte lipolysis correlates with and stimulates NAFLD when hepatocytes are lacking PPARα. Our data establish that hepatocyte-restricted Pparα deletion is sufficient to promote steatosis, emphasising this receptor's relevance as a drug target in NAFLD.
