with greater dopamine release in response to ethanol in both species. Interestingly, Ramchandani et al. (2011) did not observe a difference in receptor binding between the two lines. Taken together, these findings suggest that this SNP is especially likely to influence the initial response to multiple different drugs of abuse, thus altering the early stages of the addiction process (Stage 2 in Table 1). Mouse models have been a valuable tool for establishing the importance of this SNP both in terms of functional/anatomical intermediates and in terms of the behavioral endpoints.
